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ZYME

๐Ÿฅ Healthcare

Zymeworks Inc.

Conservative #967Aggressive #930Moderate RiskModerate 71
$23.72-1.66%
Day High$24.03
Day Low$22.94
Volume0.3M
Mkt Cap$1.8B
52W Low $952W High $28
Market Cap
$1.7B
P/E Ratio
N/A
Rev Growth
0.4%
Sector avg: 161.5%
Earnings Growth
-3.4%
Profit Margin
-47.2%
Sector avg: -3292.7%
Debt/Equity
0.06

Why This Score

ZYME scores 35.4 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Strengths
  • Minimal leverage (D/E 0.06) provides financial flexibility and downside protection.
  • High conviction (71/100) โ€” fundamental and ML signals agree on this stock.
Risk Factors
  • Signal divergence: Fundamental and ML signals disagree by a significant margin, reducing confidence.
  • Above-average volatility (14.7%) may not suit conservative risk tolerance.

Moderate penalties (-8.6 points) reflect identified risk factors. The overall score balances these against the stock's fundamental strengths.

Score Breakdown

Overall Score35.4
Fundamental Score48.1
ML Score16.0

Score by Horizon

3 Month
45.4
6 Month
50.8
Primary
1 Year
53.4

Quality Assessment

A
Earnings Grade
Strong fundamentals, high earnings quality
Quality Flags
Pipeline concentration: $1.7B biotech/pharma โ€” likely single-product revenue with binary risk
Speculative Classification
Speculative growth โ€” negative margins and ROE with momentum-driven price action. High risk of mean reversion.
Speculative micro-cap โ€” no earnings, sub-$2B market cap, momentum-driven. Position sizing should reflect elevated risk.
Conservative score reduced by 6 points.

Position Sizing

Suggested Allocation
5%
Confidence
medium

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
100
Advancing
Sentiment (2.5%)
77
Positive
Analyst (6.4%)
50
Neutral
Tradability (post-hoc)
85
Grade A
Base
35.7
SHAP
+1.3
Factors
+1.0
Divergence
-2.6
Final
35.4
Positive adjustment
Negative adjustment
Base blend
Final score

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)49.0
Technical (Momentum, Weinstein, Volatility)88.0
External (Sentiment, Analyst, Macro)82.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage89%

Growth Estimates

Short-term
-1.6% to +2.5%
Medium-term
-1.9% to +4.4%
Long-term
-2.1% to +6.3%

ML Model Core Features100 trained inputs โ†’ ML Score: 16

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score50.0/100
Target Upside+51.9%
Coverage0 analysts
Market Sentiment
Sentiment Score77.0/100
News Volume1 articles
Technical Stage
Weinstein Stage2 โ€” Advancing
12M Momentum+0.7%
6M Momentum+0.5%
Volatility+0.1%
Momentum & Technical
Momentum Acceleration+16.1%
Momentum ConsistencyStrong (0.77)
Relative Strength vs Sector+44.3%
Trend Strength (ADX Proxy)Strong (4.7)
Momentum Quality+0.579
Momentum BreadthBroad โœ“
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
5%
Low risk
Sector RevGr Rank
P42
Revenue growth vs Healthcare peers
Sector PE Rank
P22
Valuation vs Healthcare peers
Sector FCF Rank
P40
Free cash flow vs Healthcare peers
Growth Deviation
-0.0ฯƒ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 69 relative to sector peers69/100
Machine learning model ranks this stock at the 54th percentileP54
ML model weight reduced to 9% due to macro conditions: market in extended rally phase; yield curve inverted (recession indicator); late-cycle economic indicators detected9% ML weight
SHAP feature alignment: +1.3pt (features align with model priorities)โ€”
Blend: 91% fund (68.6) + 9% ML (52.8) + SHAP(+1.3) = 68.5โ€”
Factor quality: +1.0pt (multi-factor composite)โ€”
Risk assessment: moderate. Annualized volatility 14.7%. Max drawdown 16% (-3.1 pts)Moderate
Market cap adjustment: -8.0 points ($1.7B market cap)-8.0 pts
Risk Factors
Earnings quality grade A: strong earnings quality and financial health. Score adjusted by -7 pointsGrade A
Quality concern: Pipeline concentration: $1.7B biotech/pharma โ€” likely single-product revenue with binary riskFlag

Sector Peer Comparison(Healthcare โ€” Rank #153 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
ZYME35.4N/A0.4%-47.2%$1.7B
INCY89.915.821.2%25.0%$19.6B
GMAB86.113.122.8%36.4%$17.9B
CPRX83.713.723.5%37.6%$3.0B
EXEL78.315.17.0%33.7%$11.9B
ASND78.216.698.0%-31.7%$13.8B
VRTX78.232.18.9%32.9%$121.8B
NBIX75.126.521.4%16.7%$13.1B
RPRX75.025.15.1%32.4%$19.3B
HOLX74.831.11.7%13.8%$16.8B
AMGN74.226.010.0%21.0%$204.8B
ARGX73.735.178.6%38.0%$47.4B
REGN73.019.41.0%31.4%$80.2B
ALKS72.916.5-6.4%23.9%$5.0B
ISRG72.761.720.5%28.4%$180.9B
KRYS71.541.4473.0%30.7%$7.9B
Sector Average36.441.9161.5%-3292.7%โ€”

Market Sentimentvia FMP

Analyst Consensus
Buy20 analysts
Buy: 18Hold: 2
Price Target
$35consensus
Low $26Median $35High $40
+46.2% to consensus target

Company Overviewvia FMP

Zymeworks Inc., a clinical-stage biopharmaceutical company, discovers, develops, and commercializes biotherapeutics for the treatment of cancer. The company's lead product candidates include zanidatamab, a novel bispecific antibody that is in Phase 1 and Phase 2 clinical trials for the treatment of biliary tract, gastroesophageal adenocarcinomas, breast, and colorectal cancer; and ZW49, a biparatopic anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate that is in Phase 1 clinical trial for the treatment of advanced or metastatic HER2-expressing tumors. The company has strategic partnerships with Merck Sharp & Dohme Research Ltd.; Eli Lilly and Company; Bristol-Myers Squibb company; GlaxoSmithKline Intellectual Property Development Ltd.; Daiichi Sankyo Co., Ltd.; Janssen Biotech, Inc.; BeiGene, Ltd.; and Exelixis, Inc. It also has licensing and research collaboration with LEO Pharma A/S to research, develop, and commercialize bispecific antibodies; and Iconic Therapeutics, Inc. Zymeworks Inc. was incorporated in 2003 and is headquartered in Vancouver, Canada.

CEO
Kenneth H. Galbraith
Employees
299
Beta
1.24
Industry
Biotechnology
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
64.9
Neutral
Trend
Bearish
10-day vs 50-day MA
From 52W High
-16.8%
High: $28.49
From 52W Low
+162.4%
Low: $9.03
Moving Averages
10-Day
$23.20
Above
20-Day
$23.00
Above
50-Day
$24.20
Below
200-Day
$18.10
Above
60-Day Support
$21.93
60-Day Resistance
$27.94
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 2 โ€” AdvancingScore: 90/100

Stock is in an uptrend above the 200-day moving average. This is the stage where institutional accumulation typically occurs. The 50-day SMA provides support.

Favorable technical position; 50-day SMA acts as support
Price vs 200 SMA
+30.9%
200 SMA Slope (60d)
+25.06%
Rising
Volume Ratio
0.69x
10d avg vs 50d avg
Days in Stage
100
Confidence: 90%

Financial Statementslast 4 quarters via FMP

MetricQ3 2025Q2 2025Q1 2025Q4 2024
Revenue$28M$49M$27M$31M
Gross Profit$28M$49M$27M$31M
Operating Income$-22M$-674,000$-26M$-22M
Net Income$-20M$2M$-23M$-24M
EPS (Diluted)$-0.26$0.03$-0.30$-0.31
Gross Margin100.0%100.0%100.0%100.0%
Operating Margin-80.1%-1.4%-94.5%-71.6%
Net Margin-71.0%4.8%-83.5%-75.8%

Why This Stock

Healthcare

Tradability FilterGrade A โ€” 85/100Score impact: -16.2pt

Volume
97
913K avg/day
Dollar Vol
81
$21M/day
Float
90
74M shares
Mkt Cap
54
$1.7B
Range
100
216% spread
Composite Liquidity Score85/100
FDCBA

Multi-Year Range Analysis

Sideways: 0/100
YearLowHighRangeStatus
2021$14.90$42.1695.5%Wide
2022$4.11$17.27123.1%Wide
2023$6.02$10.9958.5%Wide
2024$7.97$17.7075.8%Wide
2025$9.03$28.49103.7%Wide
3-Year Range
130.3%
Narrow Years
0 / 5
Sideways Penalty
None
Free Float
98.7%
Outstanding Shares
75M
Bid-Ask Spread
216.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.