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MAZE

๐Ÿฅ Healthcare

Maze Therapeutics, Inc.

Conservative #1039Aggressive #312Moderate RiskFโ†‘ 40pt
$45.84-2.94%
Day High$47.27
Day Low$44.62
Volume0.3M
Mkt Cap$2.2B
52W Low $752W High $49
Market Cap
$2.2B
P/E Ratio
N/A
Rev Growth
0.0%
Sector avg: 161.5%
Earnings Growth
152.0%
Profit Margin
0.0%
Sector avg: -3292.7%
Debt/Equity
0.06

Why This Score

MAZE scores 32.2 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Strengths
  • Minimal leverage (D/E 0.06) provides financial flexibility and downside protection.
Risk Factors
  • Momentum reversion risk: Extreme momentum (276%) increases mean-reversion probability. 5-point penalty applied.
  • Liquidity concern: Limited trading volume or float results in a 2-point penalty for execution risk.
  • Above-average volatility (23.1%) may not suit conservative risk tolerance.

Net penalties of -16.3 points significantly impact the ranking. Without these adjustments, MAZE would rank considerably higher.

Score Breakdown

Overall Score32.2
Fundamental Score40.4
ML Score57.0

Score by Horizon

3 Month
14.1
6 Month
15.8
Primary
1 Year
16.6

Quality Assessment

F
Quality Grade
Low quality โ€” significant fundamental weaknesses
1 quality flag detected โ€” see details below. These penalties are already factored into the final score.
Quality Flags
Pipeline concentration: $2.1B biotech/pharma โ€” likely single-product revenue with binary risk

Position Sizing

Suggested Allocation
3.5%
Confidence
high

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
100
Advancing
Sentiment (2.5%)
72
Positive
Analyst (6.4%)
75
Favorable
Tradability (post-hoc)
68
Grade Blow float
Base
36.7
SHAP
+0.3
Factors
-0.2
Conviction
-4.3
Divergence
-0.2
Final
32.2
Positive adjustment
Negative adjustment
Base blend
Final score

Factor Breakdown

42AVG
Value50
Quality7
Growth70
Stability72
Investment10

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)58.0
Technical (Momentum, Weinstein, Volatility)84.0
External (Sentiment, Analyst, Macro)87.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage89%

Growth Estimates

Short-term
-9.5% to -3.7%
Medium-term
-12.5% to -4.2%
Long-term
-15.5% to -4.7%

ML Model Core Features100 trained inputs โ†’ ML Score: 57

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score75.0/100
Target Upside+12.0%
Coverage5 analysts
Market Sentiment
Sentiment Score72.0/100
News Volume1 articles
Technical Stage
Weinstein Stage2 โ€” Advancing
12M Momentum+2.8%
6M Momentum+2.2%
Volatility+0.2%
Momentum & Technical
Momentum Acceleration+58.7%
Momentum ConsistencyStrong (0.79)
Relative Strength vs Sector+251.8%
Trend Strength (ADX Proxy)Strong (5.0)
Momentum Quality+2.320
Momentum BreadthBroad โœ“
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
5%
Low risk
Sector RevGr Rank
P41
Revenue growth vs Healthcare peers
Sector PE Rank
P22
Valuation vs Healthcare peers
Sector FCF Rank
P37
Free cash flow vs Healthcare peers
Growth Deviation
-0.0ฯƒ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 40 relative to sector peers40/100
Machine learning ensemble ranks this stock at the 57th percentileP57
Blended score: 80% fundamental (40) + 20% ML (57) = 43.743.7
Risk assessment: low. Low vol 0.2%; Drawdown 16% โ†’ 0.0pt; Positive momentum 276% โ†’ -5.0ptLow
Earnings quality grade F: quality flags triggered โ€” see details below. Score adjusted by 0 pointsGrade F
SHAP feature alignment: +0.3pt (features align with model priorities)SHAP
Conviction adj: -4.3pt (conviction=N/A)Conviction
Divergence penalty: -0.2pt (ML 17pt higher)Divergence
Risk Factors
Quality concern: Pipeline concentration: $2.1B biotech/pharma โ€” likely single-product revenue with binary riskFlag
Liquidity penalty: -2.0pt (grade B)Liquidity

Sector Peer Comparison(Healthcare โ€” Rank #182 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
MAZE32.2N/A0.0%0.0%$2.2B
INCY89.915.821.2%25.0%$19.6B
GMAB86.113.122.8%36.4%$17.9B
CPRX83.713.723.5%37.6%$3.0B
ASND78.316.698.0%-31.7%$13.8B
EXEL78.315.17.0%33.7%$11.9B
VRTX78.232.18.9%32.9%$121.8B
NBIX75.126.521.4%16.7%$13.1B
RPRX75.025.15.1%32.4%$19.3B
HOLX74.831.11.7%13.8%$16.8B
AMGN74.226.010.0%21.0%$204.8B
ARGX73.735.178.6%38.0%$47.4B
REGN73.019.41.0%31.4%$80.2B
ALKS72.916.5-6.4%23.9%$5.0B
ISRG72.761.720.5%28.4%$180.9B
KRYS71.541.4473.0%30.7%$7.9B
Sector Average36.641.9161.5%-3292.7%โ€”

Market Sentimentvia FMP

Analyst Consensus
Buy5 analysts
Buy: 5
Price Target
$51consensus
Low $46Median $48High $60
+11.3% to consensus target

Company Overviewvia FMP

Maze Therapeutics, Inc., a clinical stage biopharmaceutical company, develops small molecule precision medicines for the treatment of renal, cardiovascular, related metabolic diseases, and obesity in the United States. Its lead programs includes MZE829, an oral small molecule inhibitor of apolipoprotein L1, which is in phase II clinical trial for the treatment of patients with APOL1 kidney disease; and MZE782, an oral small molecule inhibitor of the solute transporter SLC6A19, which is in phase I clinical trial for the treatment of chronic kidney disease. Maze Therapeutics, Inc. was formerly known as Modulus Therapeutics, Inc. and changed its name to Maze Therapeutics, Inc. in September 2018. The company was incorporated in 2017 and is based in South San Francisco, California.

CEO
Jason V. Coloma
Employees
125
Beta
4.52
Industry
Biotechnology
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
56.1
Neutral
Trend
Bullish
10-day vs 50-day MA
From 52W High
-6.9%
High: $49.25
From 52W Low
+583.2%
Low: $6.71
Moving Averages
10-Day
$45.80
Above
20-Day
$46.10
Below
50-Day
$43.30
Above
200-Day
$26.70
Above
60-Day Support
$36.84
60-Day Resistance
$49.25
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 2 โ€” AdvancingScore: 90/100

Stock is in an uptrend above the 200-day moving average. This is the stage where institutional accumulation typically occurs. The 50-day SMA provides support.

Favorable technical position; 50-day SMA acts as support
Price vs 200 SMA
+71.7%
200 SMA Slope (60d)
+56.92%
Rising
Volume Ratio
0.86x
10d avg vs 50d avg
Days in Stage
69
Confidence: 90%

Financial Statementslast 4 quarters via FMP

MetricQ3 2025Q2 2025Q1 2025Q4 2024
Revenue$0$0$0$0
Gross Profit$0$-649,000$0$0
Operating Income$-33M$-36M$-35M$-30M
Net Income$-30M$-34M$-33M$-30M
EPS (Diluted)$-0.66$-0.77$-0.75$-0.11
Gross MarginN/AN/AN/AN/A
Operating MarginN/AN/AN/AN/A
Net MarginN/AN/AN/AN/A

Why This Stock

Healthcare

Tradability FilterGrade B โ€” 68/100Score impact: -42.3pt

Volume
76
456K avg/day
Dollar Vol
81
$21M/day
Float
30
14M shares
Mkt Cap
60
$2.2B
Range
100
634% spread
Composite Liquidity Score68/100
FDCBA
low float
Free Float
28.9%
Outstanding Shares
48M
Bid-Ask Spread
634.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.