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14

NTLA

๐Ÿฅ Healthcare

Intellia Therapeutics, Inc.

Conservative #1342Aggressive #1031High RiskModerate 75
$13.97+4.14%
Day High$14.12
Day Low$12.70
Volume3.7M
Mkt Cap$1.6B
52W Low $652W High $28
Market Cap
$1.5B
P/E Ratio
N/A
Rev Growth
59.6%
Sector avg: 161.5%
Earnings Growth
-7.9%
Profit Margin
-774.9%
Sector avg: -3292.7%
Debt/Equity
0.13

Why This Score

NTLA scores 14.3 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Strengths
  • Positive but moderate momentum (18%) โ€” steady appreciation without overheating.
  • High conviction (75/100) โ€” fundamental and ML signals agree on this stock.
Risk Factors
  • Above-average volatility (29.0%) may not suit conservative risk tolerance.

Moderate penalties (-5.2 points) reflect identified risk factors. The overall score balances these against the stock's fundamental strengths.

Score Breakdown

Overall Score14.3
Fundamental Score21.9
ML Score4.0

Score by Horizon

3 Month
28.7
6 Month
32.1
Primary
1 Year
33.8

Quality Assessment

D
Earnings Grade
Weak fundamentals or significant quality concerns
Quality Flags
Pipeline concentration: $1.5B biotech/pharma โ€” likely single-product revenue with binary risk
Speculative Classification
Anomalous margin data โ€” extreme values suggest one-time events or accounting irregularities.
Conservative score reduced by 4 points.

Position Sizing

Suggested Allocation
2.8%
Confidence
high

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
100
Advancing
Sentiment (2.5%)
71
Positive
Analyst (6.4%)
67
Favorable
Tradability (post-hoc)
93
Grade A
Base
14.4
SHAP
+0.7
Factors
-0.4
Divergence
-0.4
Final
14.3
Positive adjustment
Negative adjustment
Base blend
Final score

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)56.0
Technical (Momentum, Weinstein, Volatility)54.0
External (Sentiment, Analyst, Macro)84.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage89%

Growth Estimates

Short-term
-8.2% to -3.2%
Medium-term
-11.0% to -3.6%
Long-term
-13.8% to -4.1%

ML Model Core Features100 trained inputs โ†’ ML Score: 4

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score66.5/100
Target Upside+51.6%
Coverage38 analysts
Market Sentiment
Sentiment Score71.3/100
News Volume1 articles
Technical Stage
Weinstein Stage2 โ€” Advancing
12M Momentum+0.2%
6M Momentum+0.0%
Volatility+0.3%
Momentum & Technical
Momentum Acceleration+13.1%
Momentum ConsistencyWeak (0.26)
Relative Strength vs Sector-6.8%
Trend Strength (ADX Proxy)Weak (0.6)
Momentum Quality+0.092
Momentum BreadthBroad โœ“
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
0%
Low risk
Sector RevGr Rank
P87
Revenue growth vs Healthcare peers
Sector PE Rank
P22
Valuation vs Healthcare peers
Sector FCF Rank
P4
Free cash flow vs Healthcare peers
Growth Deviation
+0.0ฯƒ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 46 relative to sector peers46/100
Machine learning model ranks this stock at the 41th percentileP41
ML model weight reduced to 9% due to macro conditions: market in extended rally phase; yield curve inverted (recession indicator); late-cycle economic indicators detected9% ML weight
SHAP feature alignment: +0.7pt (features align with model priorities)โ€”
Blend: 91% fund (46.0) + 9% ML (39.8) + SHAP(+0.7) = 46.1โ€”
Factor quality: -0.4pt (multi-factor composite)โ€”
Market cap adjustment: -8.0 points ($1.5B market cap)-8.0 pts
Risk Factors
Risk assessment: high. Annualized volatility 29.0%. Max drawdown 48% (-12.0 pts)High
Earnings quality grade D: weak earnings quality, multiple concerns. Score adjusted by -30 pointsGrade D
Quality concern: Non-operating gain: net margin (-774.9%) exceeds operating margin (-832.2%) by 57pp โ€” likely one-time item; Pipeline concentration: $1.5B biotech/pharma โ€” likely single-product revenue with binary riskFlag

Sector Peer Comparison(Healthcare โ€” Rank #313 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
NTLA14.3N/A59.6%-774.9%$1.5B
INCY89.915.821.2%25.0%$19.6B
GMAB86.113.122.8%36.4%$17.9B
CPRX83.713.723.5%37.6%$3.0B
EXEL78.315.17.0%33.7%$11.9B
ASND78.216.698.0%-31.7%$13.8B
VRTX78.232.18.9%32.9%$121.8B
NBIX75.126.521.4%16.7%$13.1B
RPRX75.025.15.1%32.4%$19.3B
HOLX74.831.11.7%13.8%$16.8B
AMGN74.226.010.0%21.0%$204.8B
ARGX73.735.178.6%38.0%$47.4B
REGN73.019.41.0%31.4%$80.2B
ALKS72.916.5-6.4%23.9%$5.0B
ISRG72.761.720.5%28.4%$180.9B
KRYS71.541.4473.0%30.7%$7.9B
Sector Average36.441.9161.5%-3292.7%โ€”

Company Overviewvia FMP

Intellia Therapeutics, Inc., a genome editing company, focuses on the development of therapeutics. The company's in vivo programs include NTLA-2001, which is in Phase 1 clinical trial for the treatment of transthyretin amyloidosis; and NTLA-2002 for the treatment of hereditary angioedema, as well as other liver-focused programs comprising hemophilia A and hemophilia B, hyperoxaluria Type 1, and alpha-1 antitrypsin deficiency. Its ex vivo pipeline includes NTLA-5001 for the treatment of acute myeloid leukemia; and proprietary programs focused on developing engineered cell therapies to treat various oncological and autoimmune disorders. In addition, it offers tools comprising of Clustered, Regularly Interspaced Short Palindromic Repeats/CRISPR associated 9 (CRISPR/Cas9) system. Intellia Therapeutics, Inc. has license and collaboration agreements with Novartis Institutes for BioMedical Research, Inc. to engineer hematopoietic stem cells for the treatment of sickle cell disease; Regeneron Pharmaceuticals, Inc. to co-develop potential products for the treatment of hemophilia A and hemophilia B; Ospedale San Raffaele; and a strategic collaboration with SparingVision SAS to develop novel genomic medicines utilizing CRISPR/Cas9 technology for the treatment of ocular diseases. The company was formerly known as AZRN, Inc. Intellia Therapeutics, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.

CEO
John Leonard
Employees
403
Beta
2.11
Industry
Biotechnology
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
74.4
Overbought
Trend
Bullish
10-day vs 50-day MA
From 52W High
-50.5%
High: $28.25
From 52W Low
+136.9%
Low: $5.9
Moving Averages
10-Day
$12.80
Above
20-Day
$12.70
Above
50-Day
$11.70
Above
200-Day
$12.20
Above
60-Day Support
$8.09
60-Day Resistance
$17.09
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 2 โ€” AdvancingScore: 74/100

Stock is in an uptrend above the 200-day moving average. This is the stage where institutional accumulation typically occurs. The 50-day SMA provides support.

Favorable technical position; 50-day SMA acts as support
Transition signal: 1โ†’2
Price vs 200 SMA
+14.6%
200 SMA Slope (60d)
+6.44%
Rising
Volume Ratio
0.56x
10d avg vs 50d avg
Days in Stage
8
Confidence: 50%

Financial Statementslast 4 quarters via FMP

MetricQ3 2025Q2 2025Q1 2025Q4 2024
Revenue$14M$14M$17M$13M
Gross Profit$-65M$14M$17M$13M
Operating Income$-111M$-110M$-121M$-136M
Net Income$-101M$-101M$-114M$-129M
EPS (Diluted)$-0.92$-0.98$-1.10$-1.27
Gross Margin-472.8%100.0%100.0%100.0%
Operating Margin-808.9%-772.2%-726.6%-1059.9%
Net Margin-735.2%-710.8%-687.6%-1001.2%

Why This Stock

HealthcareRevenue growth 59.6%

Tradability FilterGrade A โ€” 93/100Score impact: -32.3pt

Volume
100
4.8M avg/day
Dollar Vol
100
$64M/day
Float
100
110M shares
Mkt Cap
50
$1.5B
Range
100
379% spread
Composite Liquidity Score93/100
FDCBA

Multi-Year Range Analysis

Sideways: 0/100
YearLowHighRangeStatus
2021$43.86$202.73128.9%Wide
2022$32.72$119.65114.1%Wide
2023$22.67$47.4870.8%Wide
2024$11.34$34.87101.8%Wide
2025$5.90$28.25130.9%Wide
3-Year Range
155.8%
Narrow Years
0 / 5
Sideways Penalty
None
Free Float
95.0%
Outstanding Shares
116M
Bid-Ask Spread
379.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.