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PTCT

🏥 Healthcare

PTC Therapeutics, Inc.

Conservative #358Aggressive #559Low RiskHigh 82
$67.76-1.77%
Day High$69.59
Day Low$66.42
Volume1.0M
Mkt Cap$5.4B
52W Low $3652W High $88
Market Cap
$5.6B
P/E Ratio
8.1
Sector avg: 252.3
Rev Growth
-14.0%
Sector avg: 161.5%
Earnings Growth
42.0%
Profit Margin
-45.0%
Sector avg: -3292.7%
Debt/Equity
N/A

Why This Score

PTCT scores 57.8 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Strengths
  • Strong profitability: ROE of 33.1% exceeds the 15% quality threshold.
  • Attractively valued at 8.1x earnings, below the market average.
  • Minimal leverage (D/E -2.25) provides financial flexibility and downside protection.
  • Positive but moderate momentum (26%) — steady appreciation without overheating.
  • High conviction (82/100) — fundamental and ML signals agree on this stock.
Risk Factors
  • Above-average volatility (11.8%) may not suit conservative risk tolerance.

Minor adjustments (-0.1 points) applied. PTCT's rank of #358 primarily reflects its factor profile relative to the conservative weight vector.

Score Breakdown

Overall Score57.8
Fundamental Score56.7
ML Score42.0

Score by Horizon

3 Month
57.5
6 Month
64.3
Primary
1 Year
67.7

Quality Assessment

C
Earnings Grade
Mixed fundamentals, potential quality issues
Quality Flags
Negative ROIC (-51.0%) with high ROE (33.1%) — capital structure distortion (possibly negative equity or one-time gain)

Position Sizing

Suggested Allocation
5%
Confidence
medium

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
100
Advancing
Sentiment (2.5%)
54
Neutral
Analyst (6.4%)
64
Favorable
Tradability (post-hoc)
93
Grade A
Base
53.9
SHAP
+2.2
Factors
+0.7
Conviction
+1.1
Divergence
-0.1
Final
57.8
Positive adjustment
Negative adjustment
Base blend
Final score

Factor Breakdown

76AVG
Value95
Quality40
Growth75
Stability90
Investment80

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)68.0
Technical (Momentum, Weinstein, Volatility)81.0
External (Sentiment, Analyst, Macro)67.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage96%

Growth Estimates

Short-term
-1.6% to +2.5%
Medium-term
-2.1% to +4.1%
Long-term
-2.5% to +5.7%

ML Model Core Features100 trained inputs → ML Score: 42

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score63.5/100
Target Upside+0.0%
Coverage26 analysts
Market Sentiment
Sentiment Score53.8/100
News Volume1 articles
Technical Stage
Weinstein Stage2 — Advancing
12M Momentum+0.3%
6M Momentum+0.4%
Volatility+0.1%
Momentum & Technical
Momentum Acceleration-15.1%
Momentum ConsistencyModerate (0.63)
Relative Strength vs Sector+1.3%
Trend Strength (ADX Proxy)Moderate (2.2)
Momentum Quality+0.207
Momentum BreadthBroad ✓
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
19%
Moderate — watch growth
Sector RevGr Rank
P9
Revenue growth vs Healthcare peers
Sector PE Rank
P36
Valuation vs Healthcare peers
Sector FCF Rank
P59
Free cash flow vs Healthcare peers
Growth Deviation
-0.0σ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 58 relative to sector peers58/100
Machine learning model ranks this stock at the 67th percentileP67
ML model weight reduced to 9% due to macro conditions: market in extended rally phase; yield curve inverted (recession indicator); late-cycle economic indicators detected9% ML weight
SHAP feature alignment: +3.0pt (features align with model priorities)
Blend: 91% fund (57.9) + 9% ML (65.2) + SHAP(+3.0) = 61.6
Factor quality: +1.0pt (multi-factor composite)
Risk assessment: low. Annualized volatility 11.8%. Max drawdown 19% (-4.5 pts)Low
Market cap adjustment: +0.5 points ($5.6B market cap)+0.5 pts
Conviction bonus: +1.4pt (conviction=82)
Risk Factors
Earnings quality grade C: mixed earnings quality, some red flags. Score adjusted by -10 pointsGrade C
Quality concern: Negative ROIC (-51.0%) with high ROE (33.1%) — capital structure distortion (possibly negative equity or one-time gain)Flag

Sector Peer Comparison(Healthcare — Rank #48 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
PTCT57.88.1-14.0%-45.0%$5.6B
INCY89.615.821.2%25.0%$20.1B
GMAB85.513.122.8%36.4%$18.5B
CPRX82.213.723.5%37.6%$3.0B
VRTX78.032.18.9%32.9%$126.0B
ASND75.716.698.0%-31.7%$13.3B
NBIX74.726.521.4%16.7%$12.5B
ALKS74.616.5-6.4%23.9%$5.5B
AMGN73.826.010.0%21.0%$199.0B
ARGX73.635.178.6%38.0%$50.9B
HOLX73.331.11.7%13.8%$16.8B
REGN72.719.41.0%31.4%$84.9B
ISRG72.361.720.5%28.4%$172.5B
EXEL71.915.17.0%33.7%$11.7B
KRYS71.041.4473.0%30.7%$8.0B
HALO70.216.822.4%43.7%$9.3B
Sector Average37.1252.3161.5%-3292.7%

Market Sentimentvia FMP

Analyst Consensus
Buy26 analysts
Buy: 16Hold: 8Sell: 2
Price Target
$85consensus
Low $50Median $84High $120
+24.7% to consensus target

Company Overviewvia FMP

PTC Therapeutics, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of medicines to patients with rare disorders. Its portfolio pipeline includes commercial products and product candidates in various stages of development, including clinical, pre-clinical and research and discovery stages, focuses on the development of treatments for multiple therapeutic areas, such as rare diseases. The company offers Translarna and Emflaza for the treatment of Duchenne muscular dystrophy in the European Economic Area and the United States, as well as to treat nonsense mutation Duchenne muscular dystrophy in Brazil and Russia; commercializes Tegsedi and Waylivra for the treatment of rare diseases in Latin America and the Caribbean; and markets Evrysdi for the treatment of spinal muscular atrophy in adults and children two months and older in Brazil. The company's splicing platform includes PTC518, which is being developed for the treatment of Huntington's disease. PTC Therapeutics, Inc. has collaborations with F. Hoffman-La Roche Ltd and Hoffman-La Roche Inc., as well as the Spinal Muscular Atrophy Foundation to advance drug discovery and development research in regenerative medicine; and Akcea Therapeutics, Inc. to commercialize Tegsedi and Waylivra for the treatment of rare diseases in Latin America and the Caribbean. PTC Therapeutics, Inc. was incorporated in 1998 and is headquartered in South Plainfield, New Jersey.

CEO
Matthew Klein
Employees
939
Beta
0.49
Industry
Biotechnology
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
28.4
Oversold
Trend
Bearish
10-day vs 50-day MA
From 52W High
-22.6%
High: $87.5
From 52W Low
+88.5%
Low: $35.95
Moving Averages
10-Day
$69.70
Below
20-Day
$72.10
Below
50-Day
$74.60
Below
200-Day
$62.10
Above
60-Day Support
$64.67
60-Day Resistance
$86.76
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 2 — AdvancingScore: 76/100

Stock is in an uptrend above the 200-day moving average. This is the stage where institutional accumulation typically occurs. The 50-day SMA provides support.

Favorable technical position; 50-day SMA acts as support
Price vs 200 SMA
+9.1%
200 SMA Slope (60d)
+13.98%
Rising
Volume Ratio
0.94x
10d avg vs 50d avg
Days in Stage
100
Confidence: 90%

Financial Statementslast 4 quarters via FMP

MetricQ4 2025Q3 2025Q2 2025Q1 2025
Revenue$165M$211M$179M$1.2B
Gross Profit$148M$95M$167M$1.2B
Operating Income$-82M$3M$-35M$970M
Net Income$-135M$16M$-65M$867M
EPS (Diluted)$-1.67$0.20$-0.83$10.04
Gross Margin90.1%45.1%93.6%98.9%
Operating Margin-49.6%1.4%-19.5%82.5%
Net Margin-82.0%7.5%-36.3%73.7%

Why This Stock

HealthcareP/E ratio of 8.1Valuation below sector median (P/E 8.1)

Tradability FilterGrade A — 93/100Score impact: -3.4pt

Volume
100
1.6M avg/day
Dollar Vol
100
$111M/day
Float
89
73M shares
Mkt Cap
69
$5.6B
Range
100
143% spread
Composite Liquidity Score93/100
FDCBA

Multi-Year Range Analysis

Sideways: 0/100
YearLowHighRangeStatus
2021$34.85$60.6154%Wide
2022$25.01$55.5875.9%Wide
2023$17.53$59.84109.4%Wide
2024$23.58$54.1678.7%Wide
2025$35.95$87.5083.5%Wide
3-Year Range
133.2%
Narrow Years
0 / 5
Sideways Penalty
None

Growth Projection Adjustment

0.5x dampening
revenue decline

Growth estimates have been dampened based on technical and fundamental signals. This is a post-hoc adjustment to prevent overly optimistic projections for stocks showing declining momentum or deteriorating fundamentals.

Free Float
90.5%
Outstanding Shares
80M
Bid-Ask Spread
143.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.