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TGTX

🏥 Healthcare

TG Therapeutics, Inc.

Conservative #305Aggressive #138Moderate RiskMixed 54
$29.66-2.79%
Day High$30.72
Day Low$29.64
Volume2.1M
Mkt Cap$4.7B
52W Low $2552W High $46
Market Cap
$4.7B
P/E Ratio
9.6
Sector avg: 252.3
Rev Growth
40.8%
Sector avg: 161.5%
Earnings Growth
84.5%
Profit Margin
84.1%
Sector avg: -3292.7%
Debt/Equity
0.42

Why This Score

TGTX scores 59.8 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Strengths
  • Strong profitability: ROE of 133.2% exceeds the 15% quality threshold.
  • High net margin of 84.1%, indicating pricing power and operational efficiency.
  • Attractively valued at 9.6x earnings, below the market average.
Risk Factors
  • Above-average volatility (15.0%) may not suit conservative risk tolerance.

Minor adjustments (-0.8 points) applied. TGTX's rank of #305 primarily reflects its factor profile relative to the conservative weight vector.

Score Breakdown

Overall Score59.8
Fundamental Score53.7
ML Score74.0

Score by Horizon

3 Month
51.9
6 Month
58.0
Primary
1 Year
61.1

Quality Assessment

F
Earnings Grade
Weak fundamentals or significant quality concerns
Quality Flags
Pipeline concentration: $4.7B biotech/pharma — limited product diversification

Position Sizing

Suggested Allocation
5%
Confidence
high

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
0
Declining
Sentiment (2.5%)
67
Positive
Analyst (6.4%)
69
Favorable
Tradability (post-hoc)
87
Grade A
Base
57.8
SHAP
+1.8
Factors
+1.0
Divergence
-0.8
Final
59.8
Positive adjustment
Negative adjustment
Base blend
Final score

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)86.0
Technical (Momentum, Weinstein, Volatility)47.0
External (Sentiment, Analyst, Macro)84.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage89%

Growth Estimates

Short-term
-1.6% to +2.5%
Medium-term
-2.0% to +4.2%
Long-term
-2.4% to +5.9%

ML Model Core Features100 trained inputs → ML Score: 74

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score69.2/100
Target Upside+61.5%
Coverage13 analysts
Market Sentiment
Sentiment Score67.0/100
News Volume1 articles
Technical Stage
Weinstein Stage4 — Declining
12M Momentum-0.1%
6M Momentum-0.0%
Volatility+0.2%
Momentum & Technical
Momentum Acceleration-2.5%
Momentum ConsistencyModerate (0.54)
Relative Strength vs Sector-29.7%
Trend Strength (ADX Proxy)Weak (0.4)
Momentum Quality-0.033
Momentum BreadthNarrow
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
4%
Low risk
Sector RevGr Rank
P80
Revenue growth vs Healthcare peers
Sector PE Rank
P35
Valuation vs Healthcare peers
Sector FCF Rank
P51
Free cash flow vs Healthcare peers
Growth Deviation
+0.0σ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 69 relative to sector peers69/100
Machine learning model ranks this stock at the 61th percentileP61
ML model weight reduced to 9% due to macro conditions: market in extended rally phase; yield curve inverted (recession indicator); late-cycle economic indicators detected9% ML weight
SHAP feature alignment: +1.8pt (features align with model priorities)
Blend: 91% fund (68.9) + 9% ML (61.1) + SHAP(+1.8) = 70.0
Factor quality: +1.0pt (multi-factor composite)
Risk assessment: moderate. Annualized volatility 15.0%. Max drawdown 37% (-11.8 pts). Price momentum -5% (-0.1 pts)Moderate
Market cap adjustment: +0.5 points ($4.7B market cap)+0.5 pts
Risk Factors
Earnings quality grade F: assessed. Score adjusted by -30 pointsGrade F
Quality concern: Non-operating gain: net margin (84.1%) exceeds operating margin (19.3%) by 65pp — likely one-time item; High accrual ratio (115.7%) — earnings quality concern; Pipeline concentration: $4.7B biotech/pharma — limited product diversificationFlag

Sector Peer Comparison(Healthcare — Rank #40 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
TGTX59.89.640.8%84.1%$4.7B
INCY89.615.821.2%25.0%$20.1B
GMAB85.513.122.8%36.4%$18.5B
CPRX82.213.723.5%37.6%$3.0B
VRTX78.032.18.9%32.9%$126.0B
ASND75.716.698.0%-31.7%$13.3B
NBIX74.726.521.4%16.7%$12.5B
ALKS74.616.5-6.4%23.9%$5.5B
AMGN73.826.010.0%21.0%$199.0B
ARGX73.635.178.6%38.0%$50.9B
HOLX73.331.11.7%13.8%$16.8B
REGN72.719.41.0%31.4%$84.9B
ISRG72.361.720.5%28.4%$172.5B
EXEL71.915.17.0%33.7%$11.7B
KRYS71.041.4473.0%30.7%$8.0B
HALO70.216.822.4%43.7%$9.3B
Sector Average37.1252.3161.5%-3292.7%

Market Sentimentvia FMP

Analyst Consensus
Buy13 analysts
Buy: 11Hold: 1Sell: 1
Price Target
$50consensus
Low $39Median $50High $60
+66.9% to consensus target

Company Overviewvia FMP

TG Therapeutics, Inc., a commercial stage biopharmaceutical company, focuses on the acquisition, development, and commercialization of novel treatments for B-cell malignancies and autoimmune diseases. Its therapeutic product candidates include Ublituximab, an investigational glycoengineered monoclonal antibody for the treatment of B-cell non-hodgkin lymphoma, chronic lymphocytic leukemia (CLL), and relapsing forms of multiple sclerosis; and Umbralisib, an oral inhibitor of PI3K-delta and CK1-epsilon for the treatment of CLL, marginal zone lymphoma, and follicular lymphoma. The company also develops Cosibelimab, a human monoclonal antibody of IgG1 subtype that binds to programmed death-ligand 1 (PD-L1) and blocks its interactions with PD-1 and B7.1 receptors; TG-1701 is an orally available and covalently-bound Bruton's tyrosine kinase (BTK) inhibitor that exhibits selectivity to BTK compared to ibrutinib in in vitro kinase screening; and TG-1801, a bispecific CD47 and CD19 antibody. In addition, it has various licensed preclinical programs for BET, interleukin-1 receptor associated kinase-4, and GITR; and collaboration agreements with Checkpoint Therapeutics, Inc., Jiangsu Hengrui Medicine Co., Novimmune SA, Ligand Pharmaceuticals Incorporated, and Jubilant Biosys. The company has strategic alliances with LFB Biotechnologies S.A.S; GTC Biotherapeutics; LFB/GTC LLC; Ildong Pharmaceutical Co. Ltd.; and Rhizen Pharmaceuticals, S A. TG Therapeutics, Inc. was incorporated in 1993 and is headquartered in New York, New York.

CEO
Michael S. Weiss
Employees
352
Beta
1.87
Industry
Biotechnology
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
53.6
Neutral
Trend
Bearish
10-day vs 50-day MA
From 52W High
-36.2%
High: $46.48
From 52W Low
+17.3%
Low: $25.28
Moving Averages
10-Day
$29.40
Above
20-Day
$29.30
Above
50-Day
$29.90
Below
200-Day
$32.80
Below
60-Day Support
$26.89
60-Day Resistance
$33.61
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 4 — DecliningScore: 18/100

Stock is in a downtrend below the 200-day moving average. Price is below both the 50-day and 200-day SMAs, indicating sustained selling pressure.

Unfavorable technical position; wait for Stage 1 basing
Price vs 200 SMA
-9.6%
200 SMA Slope (60d)
-6.07%
Falling
Volume Ratio
0.72x
10d avg vs 50d avg
Days in Stage
86
Confidence: 90%

Financial Statementslast 4 quarters via FMP

MetricQ3 2025Q2 2025Q1 2025Q4 2024
Revenue$162M$141M$121M$108M
Gross Profit$134M$122M$105M$93M
Operating Income$29M$35M$9M$30M
Net Income$391M$28M$5M$23M
EPS (Diluted)$2.43$0.17$0.03$0.15
Gross Margin82.6%86.6%87.1%85.8%
Operating Margin18.2%24.7%7.1%27.7%
Net Margin241.7%20.0%4.2%21.6%

Why This Stock

HealthcareP/E ratio of 9.6Revenue growth 40.8%Profit margin 84.1%

Tradability FilterGrade A — 87/100Score impact: -7.2pt

Volume
100
1.8M avg/day
Dollar Vol
100
$55M/day
Float
60
0K shares
Mkt Cap
67
$4.7B
Range
100
84% spread
Composite Liquidity Score87/100
FDCBA

Multi-Year Range Analysis

Sideways: 0/100
YearLowHighRangeStatus
2021$12.62$51.30121%Wide
2022$3.48$20.69142.4%Wide
2023$6.46$35.67138.7%Wide
2024$12.84$36.8496.6%Wide
2025$25.28$46.4859.1%Wide
3-Year Range
151.2%
Narrow Years
0 / 5
Sideways Penalty
None

Growth Projection Adjustment

0.7x dampening
weinstein basing

Growth estimates have been dampened based on technical and fundamental signals. This is a post-hoc adjustment to prevent overly optimistic projections for stocks showing declining momentum or deteriorating fundamentals.

Free Float
0.0%
Outstanding Shares
0M
Bid-Ask Spread
84.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.