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TYRA

🏥 Healthcare

Tyra Biosciences, Inc.

Conservative #906Aggressive #499Low RiskLow 11F↑ 44pt
$34.50+1.83%
Day High$35.71
Day Low$33.93
Volume0.6M
Mkt Cap$1.8B
52W Low $652W High $36
Market Cap
$1.7B
P/E Ratio
N/A
Rev Growth
0.0%
Sector avg: 161.5%
Earnings Growth
-25.1%
Profit Margin
0.0%
Sector avg: -3292.7%
Debt/Equity
0.02

Why This Score

TYRA scores 38.1 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Strengths
  • Minimal leverage (D/E 0.02) provides financial flexibility and downside protection.
Risk Factors
  • Momentum reversion risk: Extreme momentum (139%) increases mean-reversion probability. 3-point penalty applied.
  • Liquidity concern: Limited trading volume or float results in a 2-point penalty for execution risk.
  • Signal divergence: Fundamental and ML signals disagree by a significant margin, reducing confidence.
  • Above-average volatility (15.8%) may not suit conservative risk tolerance.

Net penalties of -18.8 points significantly impact the ranking. Without these adjustments, TYRA would rank considerably higher.

Score Breakdown

Overall Score38.1
Fundamental Score46.0
ML Score74.0

Score by Horizon

3 Month
7.7
6 Month
8.7
Primary
1 Year
9.1

Quality Assessment

A
Earnings Grade
Strong fundamentals, high earnings quality
Quality Flags
Pipeline concentration: $1.7B biotech/pharma — likely single-product revenue with binary risk
Speculative Classification
Speculative micro-cap — no earnings, sub-$2B market cap, momentum-driven. Position sizing should reflect elevated risk.
Conservative score reduced by 3 points.

Position Sizing

Suggested Allocation
5%
Confidence
high

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
100
Advancing
Sentiment (2.5%)
86
Positive
Analyst (6.4%)
75
Favorable
Tradability (post-hoc)
78
Grade B
Base
43.6
SHAP
+0.9
Factors
-0.7
Conviction
-3.7
Divergence
-1.9
Final
38.1
Positive adjustment
Negative adjustment
Base blend
Final score

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)44.0
Technical (Momentum, Weinstein, Volatility)89.0
External (Sentiment, Analyst, Macro)90.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage89%

Growth Estimates

Short-term
-14.6% to -7.6%
Medium-term
-19.7% to -9.7%
Long-term
-24.7% to -11.8%

ML Model Core Features100 trained inputs → ML Score: 74

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score75.0/100
Target Upside+49.6%
Coverage7 analysts
Market Sentiment
Sentiment Score86.1/100
News Volume1 articles
Technical Stage
Weinstein Stage2 — Advancing
12M Momentum+1.4%
6M Momentum+1.2%
Volatility+0.2%
Momentum & Technical
Momentum Acceleration+18.1%
Momentum ConsistencyStrong (0.87)
Relative Strength vs Sector+114.6%
Trend Strength (ADX Proxy)Strong (5.0)
Momentum Quality+1.228
Momentum BreadthBroad ✓
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
8%
Low risk
Sector RevGr Rank
P41
Revenue growth vs Healthcare peers
Sector PE Rank
P40
Valuation vs Healthcare peers
Sector FCF Rank
P35
Free cash flow vs Healthcare peers
Growth Deviation
-0.0σ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 69 relative to sector peers69/100
Machine learning model ranks this stock at the 24th percentileP24
ML model weight reduced to 9% due to macro conditions: market in extended rally phase; yield curve inverted (recession indicator); late-cycle economic indicators detected9% ML weight
SHAP feature alignment: +0.9pt (features align with model priorities)—
Blend: 91% fund (68.6) + 9% ML (22.8) + SHAP(+0.9) = 65.4—
Factor quality: -0.7pt (multi-factor composite)—
Risk assessment: low. Annualized volatility 15.8%. Max drawdown 12% (-1.5 pts)Low
Momentum mean-reversion: -3.0pt (139% 12m momentum)—
Market cap adjustment: -8.0 points ($1.7B market cap)-8.0 pts
Conviction penalty: -3.7pt (conviction=11)—
Divergence penalty: -5.2pt (fund 44pt higher)—
Risk Factors
Earnings quality grade A: strong earnings quality and financial health. Score adjusted by -7 pointsGrade A
Quality concern: Pipeline concentration: $1.7B biotech/pharma — likely single-product revenue with binary riskFlag

Sector Peer Comparison(Healthcare — Rank #144 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
TYRA38.1N/A0.0%0.0%$1.7B
INCY89.615.821.2%25.0%$20.1B
GMAB85.513.122.8%36.4%$18.5B
CPRX82.213.723.5%37.6%$3.0B
VRTX78.032.18.9%32.9%$126.0B
ASND75.716.698.0%-31.7%$13.3B
NBIX74.726.521.4%16.7%$12.5B
ALKS74.616.5-6.4%23.9%$5.5B
AMGN73.826.010.0%21.0%$199.0B
ARGX73.635.178.6%38.0%$50.9B
HOLX73.331.11.7%13.8%$16.8B
REGN72.719.41.0%31.4%$84.9B
ISRG72.361.720.5%28.4%$172.5B
EXEL71.915.17.0%33.7%$11.7B
KRYS71.041.4473.0%30.7%$8.0B
HALO70.216.822.4%43.7%$9.3B
Sector Average37.1252.3161.5%-3292.7%—

Market Sentimentvia FMP

Analyst Consensus
Buy7 analysts
Buy: 7
Price Target
$50consensus
Low $42Median $50High $59
+44.3% to consensus target

Company Overviewvia FMP

Tyra Biosciences, Inc., a preclinical-stage biopharmaceutical company, focuses on developing therapies to overcome tumor resistance and enhance outcomes for patients with cancer. Its lead product candidate is TYRA-300, a selective inhibitor of fibroblast growth factor receptor (FGFR)3 for the treatment of muscle invasive bladder cancer. The company is also developing programs targeting FGFR2- intrahepatic cholangiocarcinoma,FGFR3-related achondroplasia, REarranged during transfection kinase, and FGFR4-related cancers. In addition, the company offers SNAP platform which enable rapid structural design through iterative molecular SNAPshots. Tyra Biosciences, Inc. was incorporated in 2018 and is based in Carlsbad, California.

CEO
Todd Harris
Employees
60
Beta
1.08
Industry
Biotechnology
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
63.2
Neutral
Trend
Bullish
10-day vs 50-day MA
From 52W High
-3.4%
High: $35.71
From 52W Low
+437.4%
Low: $6.42
Moving Averages
10-Day
$31.00
Above
20-Day
$31.00
Above
50-Day
$28.70
Above
200-Day
$16.80
Above
60-Day Support
$20.08
60-Day Resistance
$35.71
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 2 — AdvancingScore: 92/100

Stock is in an uptrend above the 200-day moving average. This is the stage where institutional accumulation typically occurs. The 50-day SMA provides support.

Favorable technical position; 50-day SMA acts as support
Price vs 200 SMA
+105.4%
200 SMA Slope (60d)
+44.45%
Rising
Volume Ratio
1.37x
10d avg vs 50d avg
Days in Stage
100
Confidence: 90%
Breakout Volume Confirmed

Financial Statementslast 4 quarters via FMP

MetricQ3 2025Q2 2025Q1 2025Q4 2024
Revenue$0$0$0$0
Gross Profit$0$0$0$0
Operating Income$-33M$-31M$-32M$-30M
Net Income$-30M$-28M$-28M$-26M
EPS (Diluted)$-0.50$-0.47$-0.47$-0.43
Gross MarginN/AN/AN/AN/A
Operating MarginN/AN/AN/AN/A
Net MarginN/AN/AN/AN/A

Why This Stock

Healthcare

Tradability FilterGrade B — 78/100Score impact: -28.3pt

Volume
87
665K avg/day
Dollar Vol
81
$22M/day
Float
66
36M shares
Mkt Cap
56
$1.7B
Range
100
429% spread
Composite Liquidity Score78/100
FDCBA

Multi-Year Range Analysis

Sideways: 0/100
YearLowHighRangeStatus
2022$4.93$14.2797.3%Wide
2023$6.55$19.74100.3%Wide
2024$11.24$29.6089.9%Wide
2025$6.42$26.41121.8%Wide
3-Year Range
128.7%
Narrow Years
0 / 4
Sideways Penalty
None
Free Float
67.8%
Outstanding Shares
53M
Bid-Ask Spread
429.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.