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40

TWST

๐Ÿฅ Healthcare

Twist Bioscience Corporation

Conservative #859Aggressive #117Moderate RiskHigh 95
$48.09-3.01%
Day High$50.02
Day Low$46.34
Volume0.5M
Mkt Cap$2.9B
52W Low $2352W High $58
Market Cap
$3.0B
P/E Ratio
N/A
Rev Growth
20.3%
Sector avg: 161.5%
Earnings Growth
62.8%
Profit Margin
-19.6%
Sector avg: -3292.7%
Debt/Equity
0.40

Why This Score

TWST scores 40.9 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Strengths
  • Positive but moderate momentum (27%) โ€” steady appreciation without overheating.
  • High conviction (95/100) โ€” fundamental and ML signals agree on this stock.
Risk Factors
  • Above-average volatility (16.1%) may not suit conservative risk tolerance.

Minor adjustments (0.0 points) applied. TWST's rank of #859 primarily reflects its factor profile relative to the conservative weight vector.

Score Breakdown

Overall Score40.9
Fundamental Score35.3
ML Score43.0

Score by Horizon

3 Month
53.0
6 Month
59.3
Primary
1 Year
62.4

Quality Assessment

C
Earnings Grade
Mixed fundamentals, potential quality issues

Position Sizing

Suggested Allocation
5%
Confidence
medium

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
20
Topping
Sentiment (2.5%)
56
Neutral
Analyst (6.4%)
67
Favorable
Tradability (post-hoc)
91
Grade A
Base
36.9
SHAP
+0.9
Factors
+0.7
Conviction
+2.4
Final
40.9
Positive adjustment
Negative adjustment
Base blend
Final score

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)63.0
Technical (Momentum, Weinstein, Volatility)76.0
External (Sentiment, Analyst, Macro)81.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage89%

Growth Estimates

Short-term
-0.8% to +3.5%
Medium-term
-0.4% to +6.1%
Long-term
+0.0% to +8.7%

ML Model Core Features100 trained inputs โ†’ ML Score: 43

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score67.3/100
Target Upside+2.0%
Coverage13 analysts
Market Sentiment
Sentiment Score56.4/100
News Volume1 articles
Technical Stage
Weinstein Stage3 โ€” Topping
12M Momentum+0.3%
6M Momentum+0.8%
Volatility+0.2%
Momentum & Technical
Momentum Acceleration-55.6%
Momentum ConsistencyModerate (0.32)
Relative Strength vs Sector+2.1%
Trend Strength (ADX Proxy)Moderate (1.6)
Momentum Quality+0.182
Momentum BreadthBroad โœ“
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
3%
Low risk
Sector RevGr Rank
P69
Revenue growth vs Healthcare peers
Sector PE Rank
P22
Valuation vs Healthcare peers
Sector FCF Rank
P44
Free cash flow vs Healthcare peers
Growth Deviation
+0.0ฯƒ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 65 relative to sector peers65/100
Machine learning model ranks this stock at the 62th percentileP62
ML model weight reduced to 9% due to macro conditions: market in extended rally phase; yield curve inverted (recession indicator); late-cycle economic indicators detected9% ML weight
SHAP feature alignment: +1.2pt (features align with model priorities)โ€”
Blend: 91% fund (64.9) + 9% ML (60.5) + SHAP(+1.2) = 65.7โ€”
Factor quality: +0.9pt (multi-factor composite)โ€”
Risk assessment: moderate. Annualized volatility 16.1%. Max drawdown 31% (-9.3 pts)Moderate
Market cap adjustment: -4.0 points ($3.0B market cap)-4.0 pts
Conviction bonus: +3.0pt (conviction=95)โ€”
Risk Factors
Earnings quality grade C: mixed earnings quality, some red flags. Score adjusted by -13 pointsGrade C
Quality concern: Elevated non-operating income: 15pp gap between net and operating margin; High accrual ratio (33.4%) โ€” earnings quality concernFlag

Sector Peer Comparison(Healthcare โ€” Rank #125 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
TWST40.9N/A20.3%-19.6%$3.0B
INCY89.915.821.2%25.0%$19.6B
GMAB86.113.122.8%36.4%$17.9B
CPRX83.713.723.5%37.6%$3.0B
EXEL78.315.17.0%33.7%$11.9B
ASND78.216.698.0%-31.7%$13.8B
VRTX78.232.18.9%32.9%$121.8B
NBIX75.126.521.4%16.7%$13.1B
RPRX75.025.15.1%32.4%$19.3B
HOLX74.831.11.7%13.8%$16.8B
AMGN74.226.010.0%21.0%$204.8B
ARGX73.735.178.6%38.0%$47.4B
REGN73.019.41.0%31.4%$80.2B
ALKS72.916.5-6.4%23.9%$5.0B
ISRG72.761.720.5%28.4%$180.9B
KRYS71.541.4473.0%30.7%$7.9B
Sector Average36.441.9161.5%-3292.7%โ€”

Market Sentimentvia FMP

Analyst Consensus
Buy13 analysts
Buy: 10Hold: 2Sell: 1
Price Target
$48consensus
Low $41Median $50High $52
+0.3% to consensus target

Company Overviewvia FMP

Twist Bioscience Corporation, a synthetic biology company, manufactures and sells synthetic DNA-based products. The company's DNA synthesis platform enables the manufacturing of synthetic DNA by writing DNA on a silicon chip. It offers synthetic DNA-based products, including synthetic genes, tools for sample preparation, antibody libraries for drug discovery and development, and DNA as a digital data storage medium. The company has collaboration agreements with Victorian Clinical Genetic Services; Vivlion GmbH.; Kyowa Kirin Pharmaceutical Research, Inc.; deepCDR Biologics AG; and Centogene N.V to develop advanced sequencing tools. It also has a research collaboration with Boehringer Ingelheim International GmbH to use proprietary antibody libraries to discover therapeutic antibodies against multiple targets. Twist Bioscience Corporation was incorporated in 2013 and is headquartered in South San Francisco, California.

CEO
Emily Marine Leproust
Employees
923
Beta
2.27
Industry
Medical - Diagnostics & Research
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
51.9
Neutral
Trend
Bullish
10-day vs 50-day MA
From 52W High
-16.9%
High: $57.88
From 52W Low
+106.3%
Low: $23.3
Moving Averages
10-Day
$50.00
Below
20-Day
$48.30
Below
50-Day
$41.40
Above
200-Day
$33.60
Above
60-Day Support
$28.9
60-Day Resistance
$57.88
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 3 โ€” ToppingScore: 15/100

Stock is losing momentum near highs. The 200-day SMA is flattening or beginning to turn. Historically, this stage precedes distribution.

Exercise caution; tighten risk management
Price vs 200 SMA
+43.1%
200 SMA Slope (60d)
+0.18%
Flattening
Volume Ratio
1.06x
10d avg vs 50d avg
Days in Stage
37
Confidence: 70%
Key Reversal Detected (2026-02-12)Recent Gap Down

Financial Statementslast 4 quarters via FMP

MetricQ1 2025Q4 2025Q3 2025Q2 2025
Revenue$104M$99M$96M$93M
Gross Profit$54M$51M$51M$46M
Operating Income$-33M$-30M$-30M$-42M
Net Income$-31M$-27M$20M$-39M
EPS (Diluted)$-0.50$-0.45$0.33$-0.66
Gross Margin52.0%51.3%53.4%49.6%
Operating Margin-31.7%-30.2%-31.4%-44.8%
Net Margin-29.4%-27.4%21.2%-42.4%

Why This Stock

HealthcareRevenue growth 20.3%

Tradability FilterGrade A โ€” 91/100Score impact: -29.2pt

Volume
100
1.4M avg/day
Dollar Vol
100
$66M/day
Float
83
59M shares
Mkt Cap
62
$3.0B
Range
100
148% spread
Composite Liquidity Score91/100
FDCBA
Free Float
95.4%
Outstanding Shares
61M
Bid-Ask Spread
148.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.