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9

QURE

🏥 Healthcare

uniQure N.V.

Conservative #1396Aggressive #1082High RiskLow 19F↑ 33pt
$24.87+3.50%
Day High$25.07
Day Low$23.03
Volume2.0M
Mkt Cap$1.5B
52W Low $852W High $72
Market Cap
$1.4B
P/E Ratio
N/A
Rev Growth
71.2%
Sector avg: 161.5%
Earnings Growth
22.3%
Profit Margin
-1492.9%
Sector avg: -3292.7%
Debt/Equity
0.29

Why This Score

QURE scores 8.9 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Risk Factors
  • Signal divergence: Fundamental and ML signals disagree by a significant margin, reducing confidence.
  • Above-average volatility (75.6%) may not suit conservative risk tolerance.

Net penalties of -19.3 points significantly impact the ranking. Without these adjustments, QURE would rank considerably higher.

Score Breakdown

Overall Score8.9
Fundamental Score27.4
ML Score5.0

Score by Horizon

3 Month
4.5
6 Month
5.0
Primary
1 Year
5.3

Quality Assessment

D
Earnings Grade
Weak fundamentals or significant quality concerns
Quality Flags
Pipeline concentration: $1.4B biotech/pharma — likely single-product revenue with binary risk
Speculative Classification
Speculative growth — negative margins and ROE with momentum-driven price action. High risk of mean reversion.
Anomalous margin data — extreme values suggest one-time events or accounting irregularities.
Speculative micro-cap — no earnings, sub-$2B market cap, momentum-driven. Position sizing should reflect elevated risk.
Conservative score reduced by 10 points.

Position Sizing

Suggested Allocation
1.1%
Confidence
high

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
0
Declining
Sentiment (2.5%)
89
Positive
Analyst (6.4%)
73
Favorable
Tradability (post-hoc)
81
Grade A
Base
12.9
SHAP
+1.2
Factors
-1.1
Conviction
-3.0
Divergence
-1.1
Final
8.9
Positive adjustment
Negative adjustment
Base blend
Final score

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)62.0
Technical (Momentum, Weinstein, Volatility)55.0
External (Sentiment, Analyst, Macro)91.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage89%

Growth Estimates

Short-term
-20.5% to -13.7%
Medium-term
-28.6% to -18.7%
Long-term
-36.1% to -23.1%

ML Model Core Features100 trained inputs → ML Score: 5

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score72.9/100
Target Upside+116.3%
Coverage35 analysts
Market Sentiment
Sentiment Score89.1/100
News Volume1 articles
Technical Stage
Weinstein Stage4 — Declining
12M Momentum+0.6%
6M Momentum+0.3%
Volatility+0.8%
Momentum & Technical
Momentum Acceleration+30.3%
Momentum ConsistencyModerate (0.46)
Relative Strength vs Sector+31.5%
Trend Strength (ADX Proxy)Weak (0.7)
Momentum Quality+0.169
Momentum BreadthBroad ✓
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
1%
Low risk
Sector RevGr Rank
P90
Revenue growth vs Healthcare peers
Sector PE Rank
P40
Valuation vs Healthcare peers
Sector FCF Rank
P20
Free cash flow vs Healthcare peers
Growth Deviation
+0.0σ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 53 relative to sector peers53/100
Machine learning model ranks this stock at the 19th percentileP19
ML model weight reduced to 9% due to macro conditions: market in extended rally phase; yield curve inverted (recession indicator); late-cycle economic indicators detected9% ML weight
SHAP feature alignment: +1.2pt (features align with model priorities)—
Blend: 91% fund (52.6) + 9% ML (18.9) + SHAP(+1.2) = 50.8—
Factor quality: -1.1pt (multi-factor composite)—
Market cap adjustment: -8.0 points ($1.4B market cap)-8.0 pts
Conviction penalty: -3.0pt (conviction=19)—
Divergence penalty: -3.5pt (fund 33pt higher)—
Risk Factors
Risk assessment: very_high. Annualized volatility 75.6%. Max drawdown 70% (-12.0 pts)Very_high
Earnings quality grade D: weak earnings quality, multiple concerns. Score adjusted by -22 pointsGrade D
Quality concern: Non-operating loss: operating margin (-1143.2%) exceeds net margin (-1492.9%) by 350pp — possible write-down; High accrual ratio (34.8%) — earnings quality concern; Pipeline concentration: $1.4B biotech/pharma — likely single-product revenue with binary riskFlag

Sector Peer Comparison(Healthcare — Rank #331 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
QURE8.9N/A71.2%-1492.9%$1.4B
INCY89.615.821.2%25.0%$20.1B
GMAB85.513.122.8%36.4%$18.5B
CPRX82.213.723.5%37.6%$3.0B
VRTX78.032.18.9%32.9%$126.0B
ASND75.716.698.0%-31.7%$13.3B
NBIX74.726.521.4%16.7%$12.5B
ALKS74.616.5-6.4%23.9%$5.5B
AMGN73.826.010.0%21.0%$199.0B
ARGX73.635.178.6%38.0%$50.9B
HOLX73.331.11.7%13.8%$16.8B
REGN72.719.41.0%31.4%$84.9B
ISRG72.361.720.5%28.4%$172.5B
EXEL71.915.17.0%33.7%$11.7B
KRYS71.041.4473.0%30.7%$8.0B
HALO70.216.822.4%43.7%$9.3B
Sector Average37.1252.3161.5%-3292.7%—

Market Sentimentvia FMP

Analyst Consensus
Buy35 analysts
Strong Buy: 1Buy: 30Hold: 4
Price Target
$54consensus
Low $31Median $45High $95
+116.7% to consensus target

Company Overviewvia FMP

uniQure N.V., a gene therapy company, engages in the development of treatments for patients suffering from genetic and other devastating diseases. Its lead program is Etranacogene dezaparvovec (AMT-061), which is in Phase III HOPE-B pivotal trial for the treatment of hemophilia B. The company also engages in developing AMT-130, a gene therapy that is in Phase I/II clinical study for the treatment of Huntington's disease; AMT-060, which is in Phase I/II clinical trial for the treatment of hemophilia B; AMT-210, a product candidate for the treatment of Parkinson's disease; AMT-260 for temporal lobe epilepsy; AMT-240, a preclinical product candidate for the treatment of autosomal dominant Alzheimer's disease; and AMT-161 for the treatment of amyotrophic lateral sclerosis. uniQure N.V. was founded in 1998 and is headquartered in Amsterdam, the Netherlands.

CEO
Matthew Craig Kapusta
Employees
209
Beta
0.67
Industry
Biotechnology
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
44.6
Neutral
Trend
Bearish
10-day vs 50-day MA
From 52W High
-65.2%
High: $71.5
From 52W Low
+220.5%
Low: $7.76
Moving Averages
10-Day
$23.30
Above
20-Day
$24.10
Above
50-Day
$23.60
Above
200-Day
$25.10
Below
60-Day Support
$19.29
60-Day Resistance
$28.77
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 4 — DecliningScore: 35/100

Stock is in a downtrend below the 200-day moving average. Price is below both the 50-day and 200-day SMAs, indicating sustained selling pressure.

Unfavorable technical position; wait for Stage 1 basing
Price vs 200 SMA
-0.9%
200 SMA Slope (60d)
+15.36%
Rising
Volume Ratio
0.86x
10d avg vs 50d avg
Days in Stage
10
Confidence: 40%
Recent Gap Up

Financial Statementslast 4 quarters via FMP

MetricQ3 2025Q2 2025Q1 2025Q4 2024
Revenue$4M$5M$2M$5M
Gross Profit$3M$5M$1M$5M
Operating Income$-51M$-44M$-39M$-46M
Net Income$-81M$-38M$-44M$-73M
EPS (Diluted)$-1.38$-0.69$-0.82$-1.50
Gross Margin89.2%87.5%87.4%88.1%
Operating Margin-1379.0%-833.6%-2510.0%-877.8%
Net Margin-2175.9%-716.8%-2784.7%-1403.2%

Why This Stock

HealthcareRevenue growth 71.2%

Tradability FilterGrade A — 81/100Score impact: -32.0pt

Volume
100
2.3M avg/day
Dollar Vol
100
$56M/day
Float
40
0K shares
Mkt Cap
50
$1.4B
Range
100
821% spread
Composite Liquidity Score81/100
FDCBA

Multi-Year Range Analysis

Sideways: 0/100
YearLowHighRangeStatus
2021$19.50$38.8066.2%Wide
2022$12.52$28.2577.2%Wide
2023$5.49$23.46124.1%Wide
2024$3.73$18.42132.6%Wide
2025$7.76$71.50160.8%Wide
3-Year Range
180.2%
Narrow Years
0 / 5
Sideways Penalty
None
Free Float
0.0%
Outstanding Shares
0M
Bid-Ask Spread
821.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.