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17

SNDX

๐Ÿฅ Healthcare

Syndax Pharmaceuticals, Inc.

Conservative #1316Aggressive #1176Moderate RiskModerate 64MLโ†‘ 18pt
$20.67-0.39%
Day High$20.87
Day Low$20.25
Volume1.3M
Mkt Cap$1.8B
52W Low $952W High $23
Market Cap
$1.7B
P/E Ratio
N/A
Rev Growth
0.0%
Sector avg: 161.5%
Earnings Growth
-52.3%
Profit Margin
-279.3%
Sector avg: -3292.7%
Debt/Equity
2.99

Why This Score

SNDX scores 17.3 on the Conservative profile, blending a fundamental score (80% weight, emphasizing quality and stability (84% of fundamental weight)) with a machine-learning signal (20% weight) trained on 82 features across 30 years of data.

Strengths
  • Positive but moderate momentum (31%) โ€” steady appreciation without overheating.
Risk Factors
  • Above-average volatility (25.1%) may not suit conservative risk tolerance.
  • Elevated leverage (D/E 2.99) increases financial risk in a rising-rate environment.

Moderate penalties (-3.4 points) reflect identified risk factors. The overall score balances these against the stock's fundamental strengths.

Score Breakdown

Overall Score17.3
Fundamental Score22.3
ML Score5.0

Score by Horizon

3 Month
48.3
6 Month
54.0
Primary
1 Year
56.9

Quality Assessment

F
Quality Grade
Low quality โ€” significant fundamental weaknesses
2 quality flags detected โ€” see details below. These penalties are already factored into the final score.
Quality Flags
Pipeline concentration: $1.7B biotech/pharma โ€” likely single-product revenue with binary risk
High leverage: D/E ratio of 3.0x โ€” elevated balance sheet risk
Speculative Classification
Speculative growth โ€” negative margins and ROE with momentum-driven price action. High risk of mean reversion.
Conservative score reduced by 3 points.

Position Sizing

Suggested Allocation
3.2%
Confidence
high

Score Composition Waterfall

How each component affects the final score
Backtested Scoring Levers (IC-calibrated from 30y ElasticNet)
Weinstein (12.1%)
100
Advancing
Sentiment (2.5%)
82
Positive
Analyst (6.4%)
73
Favorable
Tradability (post-hoc)
88
Grade A
Base
15.8
SHAP
+1.3
Factors
+0.5
Divergence
-0.3
Final
17.3
Positive adjustment
Negative adjustment
Base blend
Final score

Factor Breakdown

25AVG
Value50
Quality0
Growth20
Stability40
Investment14

Signal SegmentsComputed from ML features

Fundamental (Valuation, Quality, Growth)27.0
Technical (Momentum, Weinstein, Volatility)68.0
External (Sentiment, Analyst, Macro)89.0
Scores below 50 indicate weakness in that segment relative to the universe.

Data Quality

Score
Features
Confidence
Feature Coverage89%

Growth Estimates

Short-term
-2.1% to +1.9%
Medium-term
-2.7% to +3.3%
Long-term
-3.4% to +4.7%

ML Model Core Features100 trained inputs โ†’ ML Score: 5

These features are direct inputs to the machine learning model. The model was trained on these signals alongside 100 features (including 12 momentum/technical indicators) to produce the ML percentile score.

Analyst Intelligence
Consensus Score72.7/100
Target Upside+97.2%
Coverage22 analysts
Market Sentiment
Sentiment Score82.0/100
News Volume1 articles
Technical Stage
Weinstein Stage2 โ€” Advancing
12M Momentum+0.3%
6M Momentum+0.3%
Volatility+0.3%
Momentum & Technical
Momentum Acceleration+5.5%
Momentum ConsistencyStrong (0.82)
Relative Strength vs Sector+6.5%
Trend Strength (ADX Proxy)Weak (1.2)
Momentum Quality+0.205
Momentum BreadthBroad โœ“
Macro Regime
Bull RegimeYes
High Vol RegimeNo
S&P 500 Return+25.0%
Yield Curve-0.1bp

Sector-Relative AnalysisIn-model features

Value Trap Signal
1%
Low risk
Sector RevGr Rank
P41
Revenue growth vs Healthcare peers
Sector PE Rank
P22
Valuation vs Healthcare peers
Sector FCF Rank
P10
Free cash flow vs Healthcare peers
Growth Deviation
-0.0ฯƒ
Z-score vs sector median
Stagnation Flag
NO
Not flagged

Analysis Signals

Scoring Factors
Fundamental score of 22 relative to sector peers22/100
Machine learning ensemble ranks this stock at the 5th percentileP5
Blended score: 80% fundamental (22) + 20% ML (5) = 18.818.8
Risk assessment: low. Low vol 0.3%; Drawdown 34% โ†’ 0.0ptLow
Earnings quality grade F: quality flags triggered โ€” see details below. Score adjusted by 0 pointsGrade F
SHAP feature alignment: +1.3pt (features align with model priorities)SHAP
Divergence penalty: -0.3pt (ML 17pt lower)Divergence
Risk Factors
Quality concern: Pipeline concentration: $1.7B biotech/pharma โ€” likely single-product revenue with binary risk; High leverage: D/E ratio of 3.0x โ€” elevated balance sheet riskFlag
Speculative: SPEC_GROWTH (3.0pt penalty)Speculative

Sector Peer Comparison(Healthcare โ€” Rank #299 of 344 stocks)

StockScoreP/ERev GrowthMarginMkt Cap
SNDX17.3N/A0.0%-279.3%$1.7B
INCY89.915.821.2%25.0%$19.6B
GMAB86.113.122.8%36.4%$17.9B
CPRX83.713.723.5%37.6%$3.0B
ASND78.316.698.0%-31.7%$13.8B
EXEL78.315.17.0%33.7%$11.9B
VRTX78.232.18.9%32.9%$121.8B
NBIX75.126.521.4%16.7%$13.1B
RPRX75.025.15.1%32.4%$19.3B
HOLX74.831.11.7%13.8%$16.8B
AMGN74.226.010.0%21.0%$204.8B
ARGX73.735.178.6%38.0%$47.4B
REGN73.019.41.0%31.4%$80.2B
ALKS72.916.5-6.4%23.9%$5.0B
ISRG72.761.720.5%28.4%$180.9B
KRYS71.541.4473.0%30.7%$7.9B
Sector Average36.641.9161.5%-3292.7%โ€”

Market Sentimentvia FMP

Analyst Consensus
Buy22 analysts
Buy: 20Hold: 2
Price Target
$39consensus
Low $35Median $38High $44
+88.7% to consensus target

Company Overviewvia FMP

Syndax Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops therapies for the treatment of cancer. Its lead product candidates are SNDX-5613, which is in phase 1/2 clinical trial targeting the binding interaction of Menin with the mixed lineage leukemia 1 protein for the treatment of MLL-rearranged (MLLr) and nucleophosmin 1 mutant acute myeloid leukemia (NPM1c AML); and SNDX-6352 or axatilimab, a monoclonal antibody that blocks the colony stimulating factor 1, or CSF-1 receptor for the treatment of patients with chronic graft versus host disease (cGVHD). The company is also developing Entinostat. It also has collaborative research and development agreement with National Cancer Institute; a clinical trial agreement with Eastern Cooperative Oncology Group; and a license agreement with Kyowa Hakko Kirin Co., Ltd. Syndax Pharmaceuticals, Inc. was incorporated in 2005 and is headquartered in Waltham, Massachusetts.Massachusetts.

CEO
Michael A. Metzger
Employees
270
Beta
0.44
Industry
Biotechnology
FMP-Identified Peers

Technical Picturecomputed from daily prices

RSI (14)
54.7
Neutral
Trend
Bearish
10-day vs 50-day MA
From 52W High
-9.1%
High: $22.73
From 52W Low
+140.9%
Low: $8.58
Moving Averages
10-Day
$20.40
Above
20-Day
$20.70
Below
50-Day
$20.80
Below
200-Day
$15.40
Above
60-Day Support
$18.36
60-Day Resistance
$22.73
Weinstein Stage Analysisbased on 200-day SMA framework
Stage 2 โ€” AdvancingScore: 90/100

Stock is in an uptrend above the 200-day moving average. This is the stage where institutional accumulation typically occurs. The 50-day SMA provides support.

Favorable technical position; 50-day SMA acts as support
Price vs 200 SMA
+34.2%
200 SMA Slope (60d)
+17.05%
Rising
Volume Ratio
0.86x
10d avg vs 50d avg
Days in Stage
100
Confidence: 90%

Financial Statementslast 4 quarters via FMP

MetricQ3 2025Q2 2025Q1 2025Q4 2024
Revenue$46M$38M$20M$8M
Gross Profit$39M$37M$19M$8M
Operating Income$-57M$-69M$-84M$-96M
Net Income$-61M$-72M$-85M$-94M
EPS (Diluted)$-0.70$-0.83$-0.99$-1.10
Gross Margin86.1%96.6%95.6%100.0%
Operating Margin-125.2%-182.7%-417.9%-1254.8%
Net Margin-132.4%-189.3%-423.3%-1226.2%

Why This Stock

Healthcare

Tradability FilterGrade A โ€” 88/100Score impact: -30.0pt

Volume
100
1.5M avg/day
Dollar Vol
86
$29M/day
Float
89
73M shares
Mkt Cap
55
$1.7B
Range
100
165% spread
Composite Liquidity Score88/100
FDCBA
Free Float
84.5%
Outstanding Shares
87M
Bid-Ask Spread
165.0%
Institutional Tradable
Yes

Scores are generated by a multi-stage ML pipeline combining fundamental analysis, ensemble predictions, and structural risk signals. All data is for research purposes only and does not constitute financial advice. Past performance does not guarantee future results.